WORK PACKAGE 4 OBJECTIVE
To identify multi-morbidity patterns in a whole-life context, modelling its trajectories across someone’s lifetime. This includes examining lifestyle, socioeconomic, environmental and biological factors, and estimating the economic cost of multi-morbidity. Ultimately, WP4 will identify proactive health-focused actions that can be taken.
WHY IS WP4
IMPORTANT?
Understanding how our environment, lifestyle and circumstances can influence multi-morbidity later in life could lead to more targeted, earlier interventions and policies.
WP4 ACTIVITIES AND INTERLINKAGES
WP4 will perform a range of research-based, evidence-led work into multi-morbidity. As such, it is a central component of the STAGE project, and the findings will feed into other work packages throughout the project. Key tasks include:
T4.1
DEFINING MULTI-MORBIDITY
Assess consensus within the consortium about an operational definition of multi-morbidity using a life-course perspective to create a handbook to guide the project’s research on multi-morbidity. Patterns will be identified, mapped, visualised and compared using several factors.
T4.2
MODELLING MULTI-MORBIDITY
Characterising the trajectories of multimorbidity using data to explore patterns in a pre-selected set of diseases and conditions. This involves exploring how conditions cluster together and their combined impact on wellbeing and developing models to assess and project the future prevalence of multi-morbidity in individuals.
T4.3
MODELLING EXPOSURES AS MODERATORS OF AGEING TRAJECTORIES
Exploring multiple exposures (the exposome) as moderators of multi-morbidity and the influence of age on those exposures. The relationship between multi-morbidity states and the exposome will be examined along with the impact of targeted interventions.
T4.4
ECONOMIC IMPACTS
Examining the economic impacts associated with multi-morbidity, creating a framework to assess the health and socio-economic resilience of an individual to deal with multi-morbidity. ‘What-if’ policy-relevant scenario simulation will be used to understand the effects of interventions.
WP4 KEY OUTPUTS
Visualisation of Multi-Morbidity Patterns
Status: Ongoing
Multi-Morbidity Moderators of Ageing Trajectories
Status: Ongoing
Multi-Morbidity Models
Status: Ongoing
Policy Scenarios and Estimated Economic Impacts
Status: To be developed
WP4 STAKEHOLDER
IMPACTS
- A more comprehensive understanding of how multi-morbidity can affect individuals throughout their lives and interventions that can make a difference.
- Practical information on the impact of multi-morbidity and the exposome in an economic context. This will include a thorough examination of socio-economic and environmental determinants, which may help influence policy.
- Creation of predictive ‘what-if’ policy scenarios to support evidence-based policy decisions.
WP4 PARTNERS
With support from many of the STAGE partners, WP4 tasks are being undertaken by:
University of Rome Tor Vergata
Work Package Co-Lead
Italy
Amsterdam University Medical Centres
Work Package Partner
Netherlands
University of Oulu
Work Package Partner
Finland
University of Utrecht
Work Package Partner
Netherlands
University of Bristol
Work Package Partner
England
Region Hovedstaden
Work Package Co-Lead
Denmark
Erasmus University Medical Centre Rotterdam
Work Package Partner
Netherlands
University of Turin
Work Package Partner
Italy
Imperial College London
Work Package Partner
United Kingdom
“Taking a life-course approach to understand the moderators of ageing and how they influence the development of multi-morbidities will allow us to better target earlier interventions. This, together with a practical understanding of the economic impact of multi-morbidity in Europe, can help the project to influence policy priorities which work towards healthy ageing.”
Andrea Piano Mortari and Jennifer Baker (WP Co-Leaders)
Meet some of the WP4 partners in the video interview below and learn more about the work conducted by the work package.
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